Investigating inflammatory processes of plaque destabilization using proteomics
SSAR 2022
Lasse Lorentzen
Proteomics investigation of ECM remodelling
Proteomics workflow
Study design
- 21 symptomatic plaques from the carotid artery
- 7 Hard, 7 Mixed, 7 Soft plaques
- Compared by proteomics
Differentially regulated proteins

Over-representation analysis

Summary
- Soft plaques are associated with lower level of ECM proteins
- Soft plaques are associated with increased abundance of proteolytic enzymes
- ECM proteins are subject to proteolytic degradation
- ECM degradation is consistent with MMP activity
Thanks
- Prof. Michael Davies
- Prof. Henrik Sillesen, Prof. Jonas Eiberg, Karin Yeung
- Christine Chuang
- Protein Oxidation Group